H2 Histamine Blockers Concerns and Deficiencies

Ranitidine: An H2 Histamine Blocker

(common name Zantac, Pepcid)

What You Need to Know First



Ranitidine is a member of the H-2 histamine blocker family of drugs. This medicine prevents the release of acid into the stomach.  It is used to treat stomach ulcers, GERD, erosive esophagitis, and Zollinger-Ellsion syndrome. 

This is available OTC and as a prescription medication. 

While proton pump inhibitor drugs (PPI’s) have been in the news more lately due to new side effect findings, it does not mean that Histamine blockers are free of concerns. They are both used to suppress gastric secretions but they differ in how they do this. 

While these drugs are used to suppress stomach acid, be aware that we need stomach acid.  An easy to read and informative book that I suggest you get to understand why stomach acid is vital to our overall health is “Why we need stomach acid” by Wright and Lenard. 

What H-2 Histamine Blockers May Deplete

  • Folate: Folate is needed by the body to utilize vitamin B12. Zantac and similar medications inhibit folate absorption.  Thus, taking this medication may cause a deficiency in folate and B12
  • Iron: Stomach acid may facilitate iron absorption. Beta blockers reduce stomach acid and are associated with decreased dietary absorption of iron.  People with ulcers may be deficient due to blood loss.  It is best to check iron levels on your blood work. 
  • B12: Stomach acid is needed to release B12 from food so that it can be absorbed by the body. Since beta blockers reduce stomach acid, your B12 levels will also be low.  B12 supplementation does not need stomach acid.
  • Magnesium: These drugs can block the active transport of magnesium in the intestines causing low magnesium and resulting in depression.
  • Other possible nutrient deficiencies include: vitamin A, vitamin D, calcium and zinc

What you Should ask Yourself Before Taking an H-2 Histamine Blocker (or a PPI)

  • These drugs reduce stomach acid. Do you know that elevated stomach acid is your issue?  For some it could be something else and low stomach acid can cause the same symptoms as high stomach acid. 
  • These drugs are meant to be taken only short term, 4-8 weeks, but most people take these meds long term, sometimes for years. Would you rather get to the root of your problem and address it?
  • Would life style and dietary changes be better (and safer with no side effects) be better than taking a drug?

What May Be Causing Your Stomach Issues

  • Hiatal Hernia
  • Hormones (yours and those from your food)
  • Eating too much, too quickly and too late
  • Relaxation of the esophageal sphincter
  • High or low stomach acid
  • Coffee, caffeine, carbonated drink, spicy foods
  • Gall bladder issues (which can also mean liver issues since bile is made in the liver and is stored in the gallbladder)

Natural Options


It is always best to work with a professional to address your root causes and find out what would be the best method of body balance and digestive relief but here are a few things you can try on your own in the meantime. 

  • Try drinking 1 tablespoon of Braggs Apple Cider Vinegar in 8 ounces of water before a meal. If this helps, you may have low stomach acid. If it makes it worse, try ½ teaspoon of baking soda in a glass of water. If this resolves your issue, you may have high stomach acid.

o   If you have high stomach acid limit the amount of spicy foods you eat during gut healing (which includes coffee). 

o   As we age our stomach acid levels go down, thus older people tend to have low not high stomach acid. 

  • Add in digestive bitters before a meal. Bitter foods and herbs stimulate our bile and digestive juices to aid with meal digestion. 
  • Add in a digestive enzyme, a full spectrum one is best, so that is has the needed enzymes to break down your fats, sugar (carbs/starches), and proteins in the meal.
  • Chew DGL (licorice) before a meal
  • CHEW! Don’t inhale your food. Chew each bite 15-20 times.  This aids the digestive process.  It may seem simple but just this step alone can be very effective for some. 
  • Work with someone to determine if you have food intolerances. Or start by removing a food group for 2 to 4 weeks and see if the issue resolves. The main culprits include gluten, dairy, soy and corn.  

Bottom Line

Ask yourself if you want to address the cause or use symptom management. The choice is yours. 


  1. http://www.huffingtonpost.com/suzy-cohen-rph/acid-reflux-medication-_b_2522466.html
  2. Bauman, E. & Friedlander, J. (2014) Foundations in Nutrition. CA: Bauman College
  3. Bauman, E. & Friedlander, J. (2014) Therapeutics in Nutrition. CA: Bauman College
  4. Gaby, A. (2006) A-Z Guide to Drug-Herb-Vitamin Interactions. NY: Three Rivers Press
  5. Wright, J. & Lenard, L. (2001) Why Stomach Acid is Good For You. NY: M. Evanns


If you are sick and tired of feeling sick, tired, fatigued, depressed, anxious and more and have given up hope then Karen’s simple, effective, individualized and sustainable approach may be what you need. 

Karen Brennan, MSW, CNC, Board Certified in Holistic Nutrition and Herbalist is the author of Tru Foods Depression Free Nutrition Guide; How Food Supplements and herbs can be used to lift your mood and owner of Tru Foods Nutrition Services, LLC. 

For more information visit  www.trufoodsnutrition.com

Get her Food Swap Guide here to get started on your health journey today! Want more information, like her fb page here

As a nutrition professional, Karen does not treat, cure nor diagnose. This information is for educational purposes only.

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21 Reasons to avoid Energy drinks

21 Reasons to Avoid Energy drinks


Many young adults (18-35 y/o range) can be seen walking around holding a can of pure caffeine and sugar.  More often than not these cans contain more than one serving and who really drinks only half a can?  What is this doing to your health and could it have long term consequences?

Read on to find out!

Here is why I think energy drinks are a bad idea. 

You want to work out but are tired and need some motivation and energy so you take an energy drink


  • This can be deadly, especially if you are under a great deal of stress or have high blood pressure.
  • The number of hospital visits related to energy drinks has doubled from 2007-2011. 
  • It can make your heart race, cause palpitations, and increase you blood pressure and even lead to seizures and heart attacks. 
  • You don’t need that much sugar before you work- out.  An energy drink serving can have up to 10 teaspoons of sugar (40 grams).  Opt for a natural source of sugar and energy instead-have a banana or handful or grapes.

Instead of coffee just drink an energy drink or energy shot, right?

Wrong!  One leading brand of energy drink shots tops out at 570 mg. of caffeine.  This is way too much caffeine for your body to handle, especially in one large gulp! 

This much caffeine can lead to severe adrenal depletion.  This sets you up for a vicious cycle of that leads to more fatigue which means you need more and more caffeine to get through the day. If you are this low on energy and need this much caffeine it is time to look at root causes instead of managing your symptoms. 

The amount of caffeine in common energy drinks is 5 times the amount in a cup of coffee and 10 times the amount in a serving of soda. 

However, if you do want to start reducing your caffeine intake, don’t go cold turkey.  You will end up with terrible withdrawal effects from your daily habit.  Instead wean off slowly such as pouring a little bit out of each can you drink and every few days pouring out a little more.  If you go cold turkey you will end up with terrible headaches and brain fog for several days. 

If you need this much caffeine, ask yourself why?  Usually if you are using caffeine as a crutch there is an underlying issue that needs to be addressed.  While a picture on one website for energy drinks would have you thinking it is normal for everyone to have a 3o’clock slump and need a pick me up, this is  not normal to need caffeine to get through each and every day. 

But the label says it has all these herbs and vitamins and amino acids in it so it must be healthy for me!

Sorry there is no nutritional value in a sugary, caffeinated beverage. Don’t be fooled by the marketing! Energy drinks are actually labeled as dietary supplements but they are anything but that.  It is estimated that sales of Energy drinks in the US have brought them a market worth 12.5 billion and sales of these harmful drinks continues to grow. 

There have been cases of teenagers dying from the effects of too much consumption and it caused them to go into cardiac arrest.  So ask yourself, it is worth it?

  Yes, I know it mentions all these herbs it contains.  Most likely the herbs are in very small quantities and not in the right forms to provide you with any benefit. If you are looking for the benefits of the herbs then work with a nutrition/herb professional who can provide you with the best herbs for you and in the right forms. Herbs can also interact with medications so always work with a professional when ingesting herbs. 

The same applies to the vitamin and amino acids. The odds are they are using very poor quality forms which are difficult for the body to absorb.  And if you are only absorbing a very small amount then the odds are the benefits from them are doing you no good. Get your supplements from natural food sources instead. 

Can I substitute my morning smoothie with an energy drink?


You can if you want to stay on the viscous cycle of being wired and tired all the time and continue to destroy your health over time. 

If your usual smoothie is loaded with fruit then it may be better than an energy drink but still not a great choice. Don’t start your day with sugar.  Instead make a protein veggie smoothie.  For instance, water, protein powder, ¼ of an avocado, ¼ of a frozen banana, large handfuls of dark leafy greens, tablespoon of hemp seeds and/or nut butter.  You want energy-give your body what it really needs. It does not need caffeine and sugar.  If you think it does, then your body is trying to tell you something! Listen to it. 

Pros and cons of drinking energy drinks

Pros: None I can think of. I wish they didn’t even exist. 


  1. Dangerous when combined with alcohol or stimulants such as ADHD meds (Adderall, Ritalin)
  2. There is little scientific evidence that their “proprietary formulas” give someone a physical and/or mental edge.
  3. Anxiety
  4. Headaches
  5. Heart attacks, strokes
  6. 8-11% of those who are caffeine dependent show signs of depression
  7. Seizures
  8. High blood pressure
  9. Diabetes
  10. No nutritional value-empty calories, takes place of nutrient dense foods
  11. Irritability
  12. The caffeine inhibits the activity of folate, B6 and B12
  13. It can cause death
  14. Nausea, diarrhea
  15. The acids in the drinks can lead to tooth destruction, damage enamel, cause stomach damage, osteoporosis and bone fractures
  16. If it contains artificial sugar: this can lead to overconsumption as your brain is waiting for the calories to come along with the sweet taste and leads you to crave more sugar. 
  17. Premature aging
  18. Disrupts your gut flora (this alone is a major concern for mental, physical and immune health!)
  19. leads to low serotonin levels  (mood issues, depression)
  20. Dehydration
  21. Reduces cortisol levels (which can cause weakness, fatigue, anxiety, heart palpitations, depression, unable to cope with stress)

So as you can see, that energy drink to help you get through the day is not helping you but rather hurting you.  Zero pros to drinking them, 21 cons to drinking them; the choice is yours. 



Andrews, R. (nd) All about energy drinks.  http://www.precisionnutrition.com/all-about-energy-drinks.

Bauman, E. & Friedlander, J. (2014) Foundations in Nutrition.  CA: Bauman College

Bauman, E. & Friedlander, J. (2014) Therapeutic Nutrition.  CA: Bauman College

Greenfield, B. (7/09) I don’t approve of Energy drinks.  https://www.bengreenfieldfitness.com/2009/07/i-dont-approve-of-energy-drinks-and-a-bonus-video/

Meier, B. (1/12/13) More Emergency Room visits linked to Energy Drinks.  http;//www.nytimes.com/2013/01/12/business/more-emergency-room-visits-linked-to-energy-drinks-report-says.html.  

Stone, I. (3/17/14) Link between emergency room visits and energy drinks.  http://www.topmastersinhealthcare.com/link-between-emergency-room-visits-and-energy-drinks/

Gaille, B. (nd) Energy Drink Industry Statistics and Trends.  http://brandongaille.com/26-energy-drink-statistics-and-trends/


Karen Brennan, MSW, CNC, Board Certified in Holistic Nutrition (candidate), author of the E book Tru Foods Depression Free Nutrition Guide; How Food Supplements and herbs can be used to lift your mood and owner of Tru Foods Nutrition Services, LLC believes in food first when addressing the root causes to your health conditions.  For more information, visit her website at www.trufoodsnutrition.com

As a nutrition professional, Karen does not treat, cure nor diagnose. This information is for educational purposes only.

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