Probiotics Can Reduce Depression

Probiotics and Depression


Gut health is a popular subject lately and for good reason.  As Hippocrates said, “All disease begins in the Gut”.  We are only now beginning to understand how true this is, for our physical and mental health. 

Your gut is made up of bacteria.  We need to have a balance between the “good” and “bad” bacteria.  Research is indicating that having more good bacteria in our gut can impact our overall mood.  Using probiotics for depression remains controversial but data is showing that this can have a positive impact on our well-being. 

A study (1) done in 2016 showed that probiotic supplementation had a positive impact on those with depression who were under the age of 60.  (It did not show improvement in those over 65).  We need to face the fact that our brain and our gut is linked and if one is not working properly, the other is most likely not either.  A small study done in 2017 showed that probiotics reduced symptoms of depression and anxiety.  (2)

Probiotic’s may also be helpful for depression associated with bipolar. In a study published in the Journal of Psychiatric Research, they looked at the microbiome of those with bipolar and those without bipolar.  They found that those with bipolar had significantly different microbiomes than those without bipolar.  They had low levels of two strains that have been associated with overall health.  (4)

Studies show that probiotics should be considered an adjuvant to standard care for depression since it may reduce oxidative stress and thus may also lead to an increase in brain derived neurotropic factor (BDNF). (5) BDNF, a protein, is found abundantly in the brain and is found in both human serum and plasma.  Stress can reduce BDNF expression in the hippocampus. Recently BDNF has been shown to play a vital role in depression. This topic is still quite controversial and some research in this area differs. (6) There is a connection between low BDNF and depression but the verdict is still not in as to whether low BDNF is a contributing factor for depression.  At this time, we know we need to know more about BDNF and its role in depression. 

What to Take/What to Eat


Don’t stress out about the specific strains in your probiotics.  While we may see in the future, specific probiotic products made specifically for certain health issues such as depression, IBS, bipolar, anxiety or IBD, right now it is good to get a probiotic that contains a variety of strains.  You want diversity in your gut. 

While you may think you can swap out your antidepressant for a probiotic, this may not be the case.  Just taking a probiotic may not be enough to bring balance to the microbiome. (and please just don’t go off your medications. See my article on medication tapering here )

Just taking a supplement is usually not enough. It can be a good start but odds are, if you have depression, there is more you must do, including finding an individualized diet that is right for your body.

 The simplest way of doing this, is to slowly remove junk food categories from your diet. For instance, start by removing candy, and junk food that contains sugar such as donuts, pastries, and cookies.  Swap these out for healthier options such as avocado pudding, chia seed pudding, or nut butter with dark chocolate.  Then move on to another category such as salty snacks such as all the different chips and processed snacks.  Try not to replace with what may seem like healthier options (for instance, while Non-GMO corn chips are a better option, they still typically contain canola oil which is a refined, oxidized oil that contributes to systemic inflammation.  (depression can have inflammation as a root cause)

By removing the processed junk food from your diet, you will also be removing a bulk of GMO foods from your diet.  Glyphosate, the chemical that is sprayed on GMO crops has been shown to disrupt the gut and cause inflammation. By reducing the amount in your diet, you are improving gut health and reducing inflammation, both which are implicated in depression.  (3)

Probiotic Rich Foods


Adding in a variety of probiotic rich foods will be very supportive for your gut health.  Any type of food sensitivity should be addressed first by working with a nutrition professional and removing these foods since these will disrupt the gut causing leaky gut syndrome. 

Fermented foods will be rich in probiotics.  You can look up easy recipes to make your own but there are so many fermented products on the market now, that you don’t have to do this.  Look for raw fermented sauerkraut, Bubbies pickles, other fermented vegetables, raw unfiltered apple cider vinegar such as Braggs, kombucha, goat milk kefir, goat milk yogurt, kimchee, miso, tempeh.  Click here  for more information of fermented foods.



Look for a product that has a variety of strains. You can find most probiotics in the refrigerator section of your health food store. There are now also soil based and spore probiotics.  I personally use (and recommend for many of my clients) a spore based one such as megaspore.  You can mix and match. For instance, have some days with fermented foods and then days with supplementation.  You may need to work up to the probiotic dose as for some it can cause at first some digestive distress.  Even for those with sensitive stomachs, you may need to start off with fermented foods very slowly. You typically do not need a lot.  A dose of megaspore is typically 2 capsules per day and with probiotic foods, for most, 1-2 tablespoons per day of fermented veggies will suffice. 

Bottom Line

Adding in a quality probiotic supplement and probiotic rich foods is a good idea if you have depression. It is best to get tested for any food sensitivities first and to remove these foods from the diet.  Either way, dietary changes should be made instead of just adding in a couple of capsule of a probiotic daily If you want results.






If you are sick and tired of feeling sick, tired, fatigued, depressed, anxious and more and have given up hope then Karen’s simple, effective, individualized and sustainable approach may be what you need. 

Karen Brennan, MSW, CNC, Board Certified in Holistic Nutrition and Herbalist is the author of Tru Foods Depression Free Nutrition Guide; How Food Supplements and herbs can be used to lift your mood and If Life is So Good, Then Why AM I Still Depressed? Discover the root cause for your depression and learn what to do to feel better and owner of Tru Foods Nutrition Services, LLC. 

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As a nutrition professional, Karen does not treat, cure nor diagnose. This information is for educational purposes only.

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Karen is a Board Certified Holistic Nutritionist, Certified Nutrition Consultant, herbalist and has a Masters in Social Work. She has written two books on depression. She believes in addressing the root causes of depression and not symptom management. If you or your teen has depression and either has not had success with what western health has to offer or you just want to bypass medication and seek alternative help, and are ready to make small steps to improve your outlook on life, then contact Karen for a free 15 minute "First 2 things to do if you have depression" phone consult. 303-522-0381 This information provided in this article is for educational purposes only. Seek the help of your health professional before making any changes to your health and nutrition regimen.

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